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Original Research Article | OPEN ACCESS

Effect of Angelica gigas Nakai extract on hepatic damage in rats

Won Tae Kim1, Kang Min Kim2 , Jae Seon Kang1

1Department of Pharmacy; 2Department of Pharmaceutical Science and Technology, Kyungsung University, Busan, Republic of Korea.

For correspondence:-  Kang Kim   Email: kimkmks@ks.ac.kr

Accepted: 20 April 2020        Published: 31 May 2020

Citation: Kim WT, Kim KM, Kang JS. Effect of Angelica gigas Nakai extract on hepatic damage in rats. Trop J Pharm Res 2020; 19(5):1059-1064 doi: 10.4314/tjpr.v19i5.22

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the antioxidant and hepatoprotective effects of decursin and decursinol angelate (D/DA) isolated from Angelica gigas Nakai (AGN).
Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of D/DA was assessed in a rat model using blood tests, western blotting, and histopathological analyses to identify the pharmaceutical effects of D/DA on liver enzymes and liver morphology.
Results: The DPPH scavenging activity of D/DA was 47.11 µg/mL. Administration of D/DA to carbon tetrachloride (CCl4)-treated rats led to a decrease (13.59 %) in the total liver mass of control rats. Decursin and decursinol angelate also lowered the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but increased the concentrations of antioxidant enzymes in the liver, including catalase (CAT) and glutathione peroxidase (GPx). Histological examination revealed that D/DA also reduced hepatocellular damage in the rats.
Conclusion: D/DA from AGN has significant anti-hepatotoxic and antioxidant activities, and thus, is a potential herbal drug for treating liver damage. 

Keywords: Decursin, Decursinol angelate, Antihepatotoxicity, Antioxidant, Angelica gigas Nakai

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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